Postdoctoral Fellow - Structural Biology
Job posting number: #7184210 (Ref:10021910)
Posted: November 29, 2023
Salary / Pay Rate: $31.00 - $34.23 / hour
Application Deadline: Open Until Filled
About City of Hope
City of Hope's mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913,City of Hopehas grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis fornumerous breakthrough cancer medicines, as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center at its core, City of Hope brings a uniquely integrated model to patients spanning cancer care, research and development, academics and training, and innovation initiatives. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, andtreatment facilities in Atlanta, Chicago and Phoenix. City of Hope’s affiliated group of organizations includesTranslational Genomics Research InstituteandAccessHopeTM. For more information about City of Hope, follow us onFacebook,Twitter,YouTube,InstagramandLinkedIn.
City of Hope’s commitment to Diversity, Equity and Inclusion
We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.
Position Summary and Key Responsibilities
The laboratories of Dr. Jeff Perry, a Structural Biologist, and Javier Gordon Ogembo, a Vaccinologist, are currently seeking a highly motivated and talented individual to fill a postdoctoral position in the field of gamma-herpesvirus structural biology. The goal of the postdoctoral candidate will be to elucidate the mechanisms of gamma-herpesvirus entry and contribute to vaccine development.
If you are looking for a challenging and exciting opportunity to advance your research career in oncogenic gamma-herpesviruses and cancer, we invite you to join our multi-disciplinary lab. Our labs are part of the Beckman Research Institute of City of Hope, a world-renowned National Comprehensive Cancer Center located just 20 miles from Los Angeles. City of Hope provides access to state-of-the-art facilities and resources excellent for transitional science, as well as a vibrant and collaborative research community. The Beckman Research Institute of City of Hope has several facilities that are approved by the FDA for the production of investigational drugs and biologics for use in clinical trials. These facilities are designed to meet rigorous regulatory standards and ensure the safety and efficacy of products developed at City of Hope. As a postdoctoral fellow in our labs, you will have the opportunity to access these facilities and work alongside leading experts in the field, contributing to cutting-edge research projects aimed at advancing our understanding the mechanisms of viral entry, oncovirology, vaccinology, and studying the interactions between viruses and host cells. In addition to the opportunity to work on exciting research projects, City of Hope offers excellent benefits, and a supportive work environment that encourages career development and advancement.
Basic education, experience and skills required for consideration:
· Ideal candidates should have a Ph.D., Ph.D/DVM, or Ph.D/MD degree(s) in a related field and a strong background in protein biochemistry and structural biology.
· Cell culture and aseptic technique: culture, handling, and maintenance of bacterial and mammalian cells (multiple cell lines), cryopreservation.
· Protein production and structural assays: protein expression in different cell systems and purification; protein crystallography and/or cryo-electron microscopy; circular dichroism (CD) spectroscopy, mass spectrometry, isothermal calorimetry and/or surface plasmon resonance.
· Immuno-assays: western blot, ELISA, flow cytometry, immunofluorescence assay, immuno-histochemistry.
· Molecular cloning and basic DNA/RNA assays: molecular cloning, DNA/RNA isolation from cells, conventional PCR.
Preferred education, experience and skills for consideration:
· Experience in virology, cancer vaccines, T-cell immunology, and/or the use of animal models will be considered as a plus.
· Virology assays: virus production and titration, virus neutralization, plaque assays.
· Advanced DNA/RNA assays: DNA isolation from tissue, qPCR, RT-qPCR.
· Pre-clinical animal models: animal handling (mice and/or rats), immunization, blood collection, tissue processing.
· For more information about Dr. Javier Gordon Ogembo’s lab, please visit here.
· In addition, candidates should have excellent communication and interpersonal skills, strong attention to detail and excellent organizational skills. A track record of scientific productivity manifested in at least 2-3 first author publications in peer-reviewed journals, and the ability to work independently and as part of a dynamic team are a must. Previous experience working in a GLP-compliant laboratory setting will be an added advantage.
· The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
· As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
Salary / Pay Rate Information:
Pay Rate: $31.00 - $34.23 / hour
The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.