Post Doc Fellowship Positions

TGen

Phoenix, AZ

Job posting number: #7081424

Posted: July 21, 2021

Job Description

The Translational Genomics Research Institute (TGen), An Affiliate of City of Hope
Dr. Sunil Sharma's lab is seeking a Post Doc candidate. The research is focused on the
enhancement of anti-tumor immune responses using vaccines or adoptive cell therapy
(ACT) with tumor-infiltrating lymphocytes (TIL) for the treatment of solid tumors.
Dr. Nicholas Banovich in the Cancer Genomics Division is looking for Post Doc
applicants’ interest in understanding how changes in gene expression levels contribute
to complex diseases focused primarily on idiopathic pulmonary fibrosis and/or CAR T
cell therapy.
The TGen Center for Rare Childhood Disorders (C4RCD) under Dr. Vinodh Narayanan
is looking for a candidate to pursue biological validation studies that arise from genetic
discoveries made at the Center for Rare Childhood Disorders (C4RCD).  Such studies
include cell biological, molecular biological, and animal modeling to probe mechanisms
of disease and eventually lead to novel therapeutic approaches for neurogenetic
disorders. 

Dr. Floris Barthel is focused on unraveling the role of telomere dysfunction in glioma
development and evolution. We employ computational biology, evolutionary genetics,
functional genomics, and molecular biology to map the ramifications of dysfunctional
telomeres on glioma genomes. Dr. Barthel is looking for multiple Post Doc candidates:

1. Telomere Dysfunction: This project and the candidate will concentrate on
detecting telomere dysfunction from DNA sequencing. While the biochemistry of
telomere fusions has been described in detail, the genomics of this phenomenon
remains largely a mystery, predominantly due to its repetitive sequence and
origin in uncharted regions of the genome. 

2. Tumor Evolution: This project and candidate will aim to reconstruct evolutionary
and developmental lineages of gliomagenesis. The successful applicant will
employ next-generation genomic analysis (deep DNA sequencing, epigenome
profiling, single-cell RNA sequencing) across multiple image-mapped samples
per tumor to reconstruct tumor phylogenies and evolutionary trajectories in space
and time.

Dr. Johanna DiSefano is currently seeking a Post Doc candidate for her lab. The
candidate will investigate proteomic and transcriptomic signatures in blood-based
Extracellular Vesicles (EV) indicative of Non-Alcoholic Fatty Liver Disease (NAFLD).

About TGen
Translational Genomics Research Institute (TGen) is a Phoenix, Arizona-based non-profit
organization dedicated to conducting groundbreaking research with life changing results. TGen
is focused on helping patients with neurological disorders, cancer, and diabetes, through cutting
edge translational research (the process of rapidly moving research towards patient benefit). 
TGen physicians and scientists work to unravel the genetic components of both common and
rare complex diseases in adults and children. Working with collaborators in the scientific and
medical communities literally worldwide, TGen makes a substantial contribution to help our
patients through efficiency and effectiveness of the translational process. TGen is allied with
City of Hope, a world-renowned independent research and cancer and diabetes treatment
center. This precision medicine alliance enables both institutes to complement each other in
research and patient care, with City of Hope providing a significant clinical setting to advance
scientific discoveries made by TGen. For more information, visit: www.tgen.org.

What’s in it for me?
The Postdoctoral Fellowships at TGen are challenging development opportunities for early career
scientists who are committed to pursuing careers as independently funded, clinical and translational
investigators. Previous fellows have gone on to be leaders in both academia and industry.
Distinct Advantages for TGen Postdocs include:
Access to state-of-the-art technology, which includes:
 Collaborative Next-Generation Sequencing Center
 Bioinformatics & Knowledge Mining Laboratory
 High Performance Computing
 High Throughput Library Production Facility
 Center for Noninvasive Diagnostics
 Center for Proteomics
 Comprehensive Research Animal Support Facility
 Zebrafish Collaborative Center
Positions that are fully funded for at least two years.
Uniquely collaborative environment that fosters interdisciplinary “team science” with no departmental
barriers.
Competitive salary and benefits, including match 401k.
Mentorship by nationally and internationally renowned scientists and physicians.
Annual travel budget.
Relocation stipend is available.
Translational research with multidisciplinary teams of basic scientists paired with clinicians, providing
post-docs first-hand experience in the practice of precision medicine.
To Apply

If you are interested in seeing the most up to date job listings or to apply for this position, please go
to https://www.tgen.org/careers-tgen/#.WdP3F39e6Uk and submit your CV. Please take a moment
to read about our employee benefits and learn more about TGen. If you have any questions about
the company or how to apply for a position, please contact hr@tgen.org.
We value and support diversity in our workforce.
EEO/AA



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